hrp0094p1-40 | Fat, Metabolism and Obesity A | ESPE2021

Liraglutide for the Management of Childhood Obesity

Apperley Louise , Erlandson-Parry Karen , Gait Lucy , Laing Peter , Senniappan Senthil ,

Introduction: The prevalence of childhood obesity is continuing to increase worldwide and has become a major health concern. There are a number of serious complications to childhood obesity with significant long-term health implications if not managed in a timely matter. These complications include type 2 diabetes mellitus (T2DM), obstructive sleep apnoea (OSA), idiopathic intracranial hypertension (IIH) and non-alcoholic fatty liver disease (NAFLD). At presen...

hrp0094p2-198 | Fat, metabolism and obesity | ESPE2021

Successful weight loss and resolution of hepatic fibrosis in a girl with severe obesity

Apperley Louise , Erlandson-Parry Karen , Clarke Ellie , Gait Lucy , Auth Marcus , Senniappan Senthil ,

Introduction: Childhood obesity is continuing to increase worldwide resulting in a rise in the number of individuals with complications secondary to obesity. Non-alcoholic fatty liver disease (NAFLD) is seen in both adult and paediatric populations and if not treated appropriately is potentially life-threatening, as it may progress to advanced fibrosis, cirrhosis or hepatocellular carcinoma. NAFLD has now become the most common indication for liver transplant ...

hrp0094p2-233 | Fetal, neonatal endocrinology and metabolism (to include hypoglycaemia) | ESPE2021

Diazoxide Responsive Congenital Hyperinsulinism

Lohiya Nikhil , Cassidy Kelly , Yung Zoe , Erlandson-Parry Karen , Wright Samantha , Gait Lucy , Didi Mohammed , Senniappan Senthil ,

Introduction: Congenital Hyperinsulism (CHI) is a common cause of recurrent and persistent hypoglycemia in the neonatal period. Diazoxide is the first line medication used for the management of CHI. We report the clinical profile and the management outcome of a large cohort of patients with diazoxide responsive CHI.Methodology: A retrospective data collection including antenatal, perinatal and postnatal clinical parameters, laboratory di...